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Saturday, April 14, 2012. Significant Changes in HPLC System Suitability New USP Provisions Planned. A revision of General Chapter. On Chromatography is proposed in the Pharmacopeial Forum volume 38, edition 2. This new chapter has a major impact on system suitability tests SST. In the current USP 35, adjustments in the mobile phase in gradient conditions are not recommended. Now, adjustments should be possible but as they may cause changes in selectivity, they should be made with caution. On the co.CONTENT
This web page regimeofquality.blogspot.com states the following, "Saturday, April 14, 2012." We saw that the webpage said " Significant Changes in HPLC System Suitability New USP Provisions Planned." It also said " A revision of General Chapter. On Chromatography is proposed in the Pharmacopeial Forum volume 38, edition 2. This new chapter has a major impact on system suitability tests SST. In the current USP 35, adjustments in the mobile phase in gradient conditions are not recommended. Now, adjustments should be possible but as they may cause changes in selectivity, they should be made with caution."