A fundamental question in neuroscience concerns the mechanisms by which the complexity and precision of connections between cells in the nervous system is achieved. At the cellular level, this process requires the navigation of axonal processes to their appropriate target cells, the formation of synaptic contacts with postsynaptic partners and the assembly of functional synapses, specialized structures that allow the fast transmission of information.

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Our lab uses computer simulations of the brain to uncover the mechanisms responsible for normal brain function as well as neurological and psychiatric disease. The design of large pyramidal cells and molecular processing in spines are key information processing levels in the context of the thalamocortical circuit.