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Discuss the latest health news about herbal supplements. Saturday, March 18, 2006. A deficiency of thyroid hormones can affect virtually all body functions. The degree of severity of symptoms in adults range from mild and barely detectable to severe and very serious. Symptoms of underactive thyroid include fatigue, especially on waking, feeling cold easily, dry skin, depression, muscle and joint weakness and stiffness, constipation, general slowness and possible weight gain. Michael Schmidt and Jeffery B.