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It enhances wakefulness, attention capacity. But its pharmacological profile is notably different from the amphetamines. Modafinil is less likely to cause jitteriness, anxiety, or excess locomotor. Subjectively, modafinil feels smoother and cleaner than the amphetamines too. It may even be anxiolytic.

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Is a potential treatment for fibromyalgia. Offers promise as an augmentation to antidepressants. May be useful in the treatment of depression. May help partial responders to antidepressants. Is effective in hypersomnia and bipolar. Drug of choice for narcolepsy. Improves fatigue in patients with multiple sclerosis.