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Medicinal chemistry and compounds medicinal chemistry with synthesis and structure activity relationships. Structure Activity Relationship of Primaquine. Primaquine belongs to 8-Amino Quinoline derivative which is used to treat malaria. Radical cure or prevention of relapse in vivax malaria; after termination of chloroquine phosphate suppressive therapy in areas where vivax malaria is endemic. The optimal activity is obtained when the alkyl chain contains 4 to 6 carbon.

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